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Abstract. The Krüppel-like factor (KLF) family of transcription factors plays an important role in differentiation, function and homeostasis of many cell types. While their role in lymphocytes is still being determined, it is clear that these factors influence processes as varied as lymphocyte quiescence, trafficking, differentiation and function.
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Krüppel-like factors (KLFs) are a family of transcription factors characterised by zinc-finger structures at the C-terminal. They play the key roles in cell proliferation, differentiation, and migration, as well as in embryonic development. They have been widely expressed in multiple systems in vivo, and their dysregulation is closely associated with a variety of human diseases. Glycolipid.
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The KLF return 23 years after bowing out of the music industry On 23 August 1994, The KLF - one of Britain's most incendiary bands, in more ways than one - burned £1m on a remote Scottish island.
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Krüppel-like factor 10 (KLF10), originally named TGF-β (Transforming growth factor beta) inducible early gene 1 (TIEG1), is a DNA-binding transcriptional regulator containing a triple C2H2 zinc finger domain. By binding to Sp1 (specificity protein 1) sites on the DNA and interactions with other regulatory transcription factors, KLF10.
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1. ). Klf family members contain three conserved DNA-binding C 2 H 2 zinc fingers that recognize similar consensus sites ( 2. ). The N-terminal domains of the various Klfs vary, and these different domains mediate different molecular functions. Some Klfs function predominantly as activators, such as Eklf/Klf1 (erythroid Klf) ( 3.
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The band's music has been officially unavailable since 1992, when they deleted their entire back catalogue. But eight songs, including dance anthems like 3AM Eternal and What Time Is Love, are now.
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Abstract. Dysregulated Krϋppel-like factor (KLF) gene expression appears in many disease-associated pathologies. In this review, we discuss physiological functions of KLFs in the kidney with a focus on potential pharmacological modulation/therapeutic applications of these KLF proteins. KLF2 is critical to maintaining endothelial barrier.
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Strikingly, loss of function of both klf-1 and klf-3 abolished lifespan extension in the eat-2(ad1116) and food dilution on solid agar (sDR) models of dietary restriction as well as in the daf-2.
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After years of silence, The KLF have uploaded a selection of their most famous songs to streaming services like Spotify, YouTube and Apple Music. But eight songs, including dance anthems like 3AM.
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The mammalian Krüppel-like factor (KLF) family of zinc finger transcription factors has recently received increased attention. There are >15 known family members at present, and despite initial expectations that they would have redundant functions, they, in fact, have individually important biological functions, as shown by gene knockout studies (eg, KLF2, KLF4, and KLF5).
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Key Points The Krüppel-like factors (KLFs) are a family of transcriptional regulators linked by a triple zinc finger DNA-binding domain. In normal tissues, KLFs control a broad number of key.
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Dysregulated Krϋppel-like factor (KLF) gene expression appears in many disease-associated pathologies. In this review, we discuss physiological functions of KLFs in the kidney with a focus on potential pharmacological modulation/therapeutic applications of these KLF proteins.
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The KLF family is composed of at least 18 transcription factors. They are widely distributed in eukaryotes and involved in embryonic development, tissue and organ maturation, stem cell generation.